IGF-1 LR3: doses reported in published research

Sources checked 2026-10-07 · 3 cited studies (0 human, 3 animal, 0 cell culture)

IGF-1 LR3 (Long R3 IGF-I) is a recombinant analog of insulin-like growth factor I with a 13-amino-acid N-terminal extension and arginine at position 3. Published dose data come from animal studies.

No human data. no human studies of IGF-1 LR3 were found. Mecasermin (recombinant human IGF-1) is a different, FDA-approved prescription drug; its label is not summarized here because it is not the same molecule.

Animal studies (3)

Animal doses are listed exactly as the studies report them. They are not converted to human amounts here; doses do not translate between species by body weight.

Animal Rats (acute renal ischaemia model)

Dose as reported: 1.5 mg/kg per day
Route: Subcutaneous
Frequency / duration: Daily; 3 days in the second experiment

Source wording: LR3IGF-I (1.5 mg/kg per day) by s.c. treated for the latter 3 days with either vehicle (controls) or LR3IGF-I (1.5 mg/kg per day)

Martin AA, Gillespie CM, Moore L et al.. Effects of insulin-like growth factor-I peptides in rats with acute renal failure. J Endocrinol 1994. PubMed PMID 8138750 ↗

Animal Dystrophic mdx and wild-type mice

Dose as reported: About 1.5 mg/kg per day
Route: Continuous delivery by osmotic mini-pump
Frequency / duration: Continuous for 4 weeks

Source wording: were administered LR IGF-I continuously ( approximately 1.5 mg kg(-1) day(-1)) via osmotic mini-pump for 4 weeks

Gehrig SM, Ryall JG, Schertzer JD et al.. Insulin-like growth factor-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage. Exp Physiol 2008. PubMed PMID 18567600 ↗

Animal Neonatal calves (first week of life)

Dose as reported: 50 µg/kg body weight per day
Route: Subcutaneous or oral (separate groups)
Frequency / duration: Daily for 7 days

Source wording: Long-R3-IGF-I (administered subcutaneously or orally; 50 micrograms.kg body wt-1.day-1 for 7 days

Hammon H, Blum JW. The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I. Am J Physiol 1997. PubMed PMID 9252489 ↗

Half-life

No half-life value was found in the sources reviewed for this page.

About this page

Every figure above is copied from the cited source; the source wording is shown with each entry. Where a source does not state something, the page says so.
Only abstracts, open-access full texts, registry records and FDA labels were used, so details found only in a paywalled full text may be missing.
This page does not convert doses between species or into other measures, and gives no preparation or handling information.