Selank: doses reported in published research

Sources checked 2026-10-07 · 4 cited studies (0 human, 4 animal, 0 cell culture)

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of tuftsin developed in Russia. Published dose data with stated amounts are from rodent studies.

No human data. No human dose data tabulated: a Russian randomized clinical study (PMID 26356395) gave selank with phenazepam but does not state the amount in its abstract.

Animal studies (4)

Animal doses are listed exactly as the studies report them. They are not converted to human amounts here; doses do not translate between species by body weight.

Animal BALB/c and C57BL/6 mice

Dose as reported: 300 µg/kg/day
Route: Intraperitoneal or intranasal (separate groups)
Frequency / duration: Daily for 5 days

Source wording: Pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of heptapeptide selank (300 μg/kg/day for 5 days)

Vasil'eva EV, Kondrakhin EA, Salimov RM et al.. [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]. Eksp Klin Farmakol 2016. PubMed PMID 29787664 ↗

Animal Rats (9 months old; ethanol withdrawal model)

Dose as reported: 0.3 mg/kg a day
Route: Intraperitoneal
Frequency / duration: Daily for 7 days

Source wording: Selank (0.3 mg/kg a day, 7 days, intraperitoneally) in 9 months rats

Kolik LG, Nadorova AV, Antipova TA et al.. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bull Exp Biol Med 2019. PubMed PMID 31625062 ↗

Animal Morphine-dependent rats

Dose as reported: 0.3 mg/kg
Route: Intraperitoneal
Frequency / duration: Single dose

Source wording: Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg

Konstantinopolsky MA, Chernyakova IV, Kolik LG. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bull Exp Biol Med 2022. PubMed PMID 36322304 ↗

Animal Rats (frontal cortex gene expression, 1 and 3 h after dosing)

Dose as reported: 300 µg/kg
Route: Not stated in the abstract
Frequency / duration: Single dose

Source wording: in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg)

Volkova A, Shadrina M, Kolomin T et al.. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol 2016. PubMed PMID 26924987 ↗

Half-life

No half-life value was found in the sources reviewed for this page.

About this page

Every figure above is copied from the cited source; the source wording is shown with each entry. Where a source does not state something, the page says so.
Only abstracts, open-access full texts, registry records and FDA labels were used, so details found only in a paywalled full text may be missing.
This page does not convert doses between species or into other measures, and gives no preparation or handling information.